From Perciavalle
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Chronic Pain
Fibromyalgia is characterized by chronic, widespread pain. Although the cause is unknown, it has been shown to accompany several other medical conditions. Patients with fibromyalgia were subjected to 10 sessions of thermal therapy, 60 degrees C for 15 minutes in a dry sauna. All the patients experienced a significant reduction in pain, between 11-70%, after one session. Furthermore, at the end of all 10 sessions, the severity of pain was consistently reduced between 20-78%. [1] Hyperthermia, due to heat exposure in a dry sauna, causes a potent increase in beta endorphin levels, even more than exercise. [2] Beta endorphin is an important pain reliever. The body has a natural painkiller system, known as the mu opioid system. The mu opioid system produces endogenous (natural) opioids, or beta endorphins, which block the pain messages from spreading from the body to the brain, this effect is known as antinociception. Three classical opioids that are made in our bodies include endorphins, enkephalins, and dynorphins. These endogenous opioids act on the mu, delta, and kappa opioid receptors, respectively. While the mu opioid system produces endorphins, dulling pain, the kappa opioid system produces dynorphin, which is responsible for dysphoria. However, research has shown that repeated stimulation of kappa opioid receptors results in upregulation of mu opioid receptor function, release of endorphins. [3] The repeated stimulation of the kappa opioid receptors also leads to sensitization of the mu opioid receptors to endorphins, leading to the antinociceptive (painkilling) effect. [3] This means that extreme heat exposure in a sauna, intense physical activity, and spicy foods (capsaicin) all cause discomfort due to repeated stimulation of kappa opioids, which results in sensitization of mu opioids and release of beta endorphins. This is commonly known as a pain-induced release of endorphins.
Opioids have been medicinally used for centuries because of their analgesic (painkilling) effects. Morphine is really the prototype, as far as opiates go, and is used to treat both acute and chronic pain. The effects of opiates, such as morphine, mimic the effects of the endogenous (natural) opioid system.
Inflammatory Diseases
Diabetes
Type 1 Diabetes
In Type 1 diabetes, the insulin-producing beta islet cells are abolished by cytotoxic T cells, thus, no insulin is produced and blood glucose levels remain elevated. In a mouse model for type 1 diabetes, whole body hyperthermia prevented the onset of diabetes. Hyperthermia resulted in the destruction of cytotoxic T cells, and survival of the insulin producing beta islet cells. [4] These data suggest that hyperthermia could potentially be used to treat autoimmune diseases.
Type 2 Diabetes (Obesity-Induced Insulin Resistance)
Hyperthermia, due to heat exposure in a dry sauna, improves insulin resistance in an obese diabetic mouse model. Insulin resistant diabetic mice were subjected to 30 minutes of hyperthermic treatment, three times a week for twelve weeks. This resulted in a 31% decrease in insulin levels and a significant reduction in blood glucose levels, suggesting re-sensitization to insulin. [5] This suggests that sauna therapy may be a potential treatment and preventative measure for obesity-induced insulin resistance (type 2 diabetes). Furthermore, gene expression profiling was done on adipose and liver tissue from diabetic mice that were treated with whole body hyperthermia (sauna therapy). The mice that were treated with whole body hyperthermia showed significant decreases in the pro-inflammatory cytokines, NF-kappaB and IL-6 compared to untreated animals. [6] Inflammation has been implicated in the cause of type 2 diabetes, in fact, the pro-inflammatory cytokine TNF-alpha can induce insulin resistance in mice. [7] Since hyperthermia can modulate pro-inflammatory signaling pathways, sauna treatment may have potential therapeutic value as a treatment as well as prevention of inflammatory diseases, such as type 2 diabetes.
Colitis
Colitis is a digestive disease that results from chronic inflammation of the colon. Hyperthermia ameliorates clinical symptoms of colitis. [8] Hyperthermia treatment significantly reduced neutrophil chemoattractants as well as TNF-alpha in the colon. Additionally, hyperthermia induced expression of heat shock protein 70, which further attenuated inflammatory markers and resulted in improvement of clinical symptoms of colitis. [8] In another study, whole body hyperthermia induced the expression of heat shock protein 70 and heme oxygenase-1 in the small intestine and significantly reduced intestinal damage. [9]
Autoimmune Myocarditis
Myocarditis is inflammation of the heart and involves the destruction of cardio-myocytes with a 5 year survival rate. [10] Whole body hyperthermia treatment on a mouse model for experimental autoimmine myocarditis mitigates the destrustion of the cardio-myoctes. [11]
Ankylosing Spondylitis
Ankylosing Spondylitis is chronic arthritis of the spine caused by inflammation and results in fusion of the spine. Clinical studies using mild whole body hyperthermia on males with ankylosing spondylitis, found that 9 cycles of increased body temperature (37.8 degrees C) resulted in a 40-50% reduction in the pro-inflammatory cytokines TNF-alpha, IL-1beta, and IL-6. [12]
Pancreatitis
Hyperthermic treatment in a mouse model for Pancreatitis resulted in a reduction in pancreatic organ damage and a decrease in the severity of pancreatitis. [13] The protective role of hyperthermia against acute pancreatitis is mediated by heat shock protein 70 (hsp70). [14] Specifically, hsp70 prevents intrapancreatic activation of trypsinogen, which protects against pancreatitis. [14]
Hearing Loss
Hyperthermia has been shown to protect against noise-induced hearing loss. Rats that were exposed to elevated temperatures prior to loud noise, suffered significantly less auditory damage compared to rats that were did not receive hyperthermic treatment. [15] This means that hyperthermia may help protect against noise-induced hearing loss.
Cardiac Dsrhythemia
Someone with ventricular arrhythmia has an abnormal heartbeat and is common in patients with chronic heart failure (CHF). Sauna treatment has been shown to ameliorate ventricular arrhythmias in people with chronic heart failure. Patients that underwent far infrared sauna therapy were treated for 15 minutes at 60°C everyday for two weeks. The patients that were subjected to hyperthermia (sauna treatment) had a significant decrease in irregular heartbeats compared to the non-treated group. Additionally, the sauna-treated group had a considerable reduction in ventricular tachycardia which only occurred in 20% of the treated compared to 80% in the non-treated group. [16]
Coronary Risk Factors
Coronary risk factors are associated with diseases such as hyperlipidemia, hypertension, diabetes mellitus and smoking. Endothelial dysfunction is observed in all patients with coronary risk factors and is thought to be a critical factor in the cause of atherosclerosis. [17] Many studies have demonstrated that impaired vasodilation results in endothelial dysfunction. [18]
http://0-www.ncbi.nlm.nih.gov.opac.uthsc.edu/pmc/articles/PMC2359619/?tool=pubmed
http://www.jstage.jst.go.jp/article/jcj/65/5/65_434/_article/-char/en
Far Infrared Saunas
Far infrared saunas are becoming increasingly popular.
Facts to Chase
Heat exposure (15 min) in a Finnish sauna bath at an ambient temperature of 72 C, led to an increase in plasma GH levels from 2 to 5 micrograms/L (P less than 0.01) at 30 min in the younger men. Their rectal temperature had risen by 0.2 C at 15 min. Plasma immunoreactive GHRH increased from 9 to 36 ng/L (P less than 0.05) 5 min after heat exposure, and it gradually fell to the initial levels by 45 min. The older men did not have a significant increase in plasma GH or GHRH levels in response to the heat exposure. http://www.ncbi.nlm.nih.gov/pubmed/3117831
The secretion of the antidiuretic hormone is increased and the renin-angiotensin-aldosterone system is activated. The concentrations of the growth hormone and prolactin, in particular, secreted from the anterior pituitary are increased in the circulation. The concentration of the immunoreactive beta-endorphin in blood may also increase which may reflect the feeling of pleasure or, on the other hand, discomfort induced by the sauna. The changes induced by the sauna in various hormone concentrations in the circulation are, however, normalized within a couple of hours after the heat stress.
http://www.ncbi.nlm.nih.gov/pubmed/3218898
There was a significant increase in mean heart rate (62%), serum growth hormone (142%) and plasma renin activity (95%) in the Sauna. One hour after the Sauna bath the mean serum growth hormone had returned to the control level while plasma renin activity still remained higher (p less than 0.05) than before the Sauna bath. The serum insulin, blood sugar and urinary excretion of aldosterone and VMA did not change during or after Sauna bath. The urinary sodium excretion decreased significantly after the Sauna bath and the decrease was most striking (46%) during the first 6-hour period from the beginning of Sauna bath. Plasma renin activity values correlated positively with 12-hour urinary VMA excretion (p less than 0.01) and negatively with 6-hour urinary sodium excretion (p less than 0.05) before and after Sauna, suggesting the role of catecholamines and sodium depletion in renin response in Sauna. http://www.ncbi.nlm.nih.gov/pubmed/999213
Sauna therapy normalizes blood pressure and treating congestive heart failure; chronic pain; weak evidence, from a single study, chronic fatigue syndrome; therapy for obesity; cholesterol reduction. http://0-www.ncbi.nlm.nih.gov.opac.uthsc.edu/pubmed/19602651
Such diseases as hypertension, vascular endothelial dysfunction, multiple chemical sensitivity and heart failure are thought to be helped by sauna therapy and chronic fatigue syndrome and fibromyalgia may also be helped and there are others that may be good candidates for sauna therapy. http://0-www.ncbi.nlm.nih.gov.opac.uthsc.edu/pubmed/19581054
We developed a Waon therapy (soothing warm therapy) and have previously reported that repeated Waon therapy improves hemodynamics, peripheral vascular function, arrhythmias, and clinical symptoms in patients with chronic heart failure (CHF). http://0-www.ncbi.nlm.nih.gov.opac.uthsc.edu/pubmed/19304125
Regular thermal therapy, using saunas or hot baths, has the potential to improve impaired insulin sensitivity and boost endothelial expression of the "constitutive" isoform of nitric oxide synthase--effects, analogous to those of aerobic training that should promote vascular health. http://0-www.ncbi.nlm.nih.gov.opac.uthsc.edu/pubmed/19203842
Repeated sauna treatment improves vascular endothelial function, resulting in an improvement in cardiac function and clinical symptoms. http://0-www.ncbi.nlm.nih.gov.opac.uthsc.edu/pubmed/11869837
Waon therapy is safe, improves clinical symptoms and cardiac function, and decreases cardiac size in CHF patients. Waon therapy is an innovative and promising therapy for patients with CHF. http://0-www.ncbi.nlm.nih.gov.opac.uthsc.edu/pubmed/18922381
All patients experienced a significant reduction in pain by about half after the first session of Waon therapy (11-70%), and the effect of Waon therapy became stable (20-78%) after 10 treatments. Pain VAS and FIQ symptom scores were significantly (p<0.01) decreased after Waon therapy and remained low throughout the observation period. CONCLUSION: Waon therapy is effective for the treatment of fibromyalgia syndrome. http://0-www.ncbi.nlm.nih.gov.opac.uthsc.edu/pubmed/18703857
infrared treatment has statistically significant short-term beneficial effects and clinically relevant period effects during treatment in RA and AS patients without enhancing disease activity. IR has good tolerability and no adverse effects. http://0-www.ncbi.nlm.nih.gov.opac.uthsc.edu/pubmed/18685882
A decrease in casual skin sebum content on the skin surface of the forehead was observed in these volunteers. The present data suggest a protective effect of regular sauna on skin physiology, especially surface pH and stratum corneum water-holding capacity. http://0-www.ncbi.nlm.nih.gov.opac.uthsc.edu/pubmed/18525205
Repeated Waon therapy improved right ventricular positive dP/dt, PH during exercise, exercise tolerance and the QOL in patients with severe COPD. http://0-www.ncbi.nlm.nih.gov.opac.uthsc.edu/pubmed/18522783
The total peripheral resistance decreased by 11%, and the cardiac output increased by 14%. There was significant improvement in the parameters that are indicative of the peripheral circulatory status, including the skin blood flow, blood flow velocity, pulsatile index, and resistive index. Numbness and chronic myalgia of the extremities decreased. There were no adverse side effects. Thus, it can be concluded that LTSB improves the peripheral circulation in CP patients. http://0-www.ncbi.nlm.nih.gov.opac.uthsc.edu/pubmed/18196282
Sauna, mud bath, and thermal water increase betaE levels through conveying heat to the tissues. http://0-www.ncbi.nlm.nih.gov.opac.uthsc.edu/pubmed/17483960
We conclude that 3 wk of post-exercise sauna bathing produced a worthwhile enhancement of endurance running performance, probably by increasing blood volume. http://0-www.ncbi.nlm.nih.gov.opac.uthsc.edu/pubmed/16877041
Sauna was well tolerated and posed no health risks to healthy people from childhood to old age. Baths did not appear to be particularly risky to patients with hypertension, coronary heart disease and congestive heart failure, when they were medicated and in a stable condition. Excepting toxemia cases, no adverse effects of bathing during pregnancy were found, and baths were not teratogenic. In musculoskeletal disorders, baths may relieve pain. Medication in general was of no concern during a bath, apart from antihypertensive medication, which may predispose to orthostatic hypotension after bathing http://0-www.ncbi.nlm.nih.gov.opac.uthsc.edu/pubmed/16871826
These results suggest that a combination of multidisciplinary treatment and repeated thermal therapy may be a promising method for treatment of chronic pain http://0-www.ncbi.nlm.nih.gov.opac.uthsc.edu/pubmed/16088266
In obese patients, the body weight and body fat significantly decreased after 2 weeks of sauna therapy without increase of plasma ghrelin concentrations. On the basis of these data, sauna therapy may be a promising therapy for patients with lifestyle-related diseases. http://0-www.ncbi.nlm.nih.gov.opac.uthsc.edu/pubmed/14610268
Maximal increase in plasma ACTH levels occurred 15 min earlier. In the first sauna exposed group the increase in body temperature was the same (about 2 degrees C) in both sexes. Nevertheless, the elevation in plasma ACTH concentration was significantly more pronounced in women than in men. In the plasma collected at the end of sauna bath inside the sauna room, a significant rise in both adrenaline and noradrenaline levels was found. Though the catecholamine responses were similar in both groups, the increase in heart rate during sauna bath was significantly higher in women. Sauna-induced prolactin release was also more pronounced in women compared with men http://0-www.ncbi.nlm.nih.gov.opac.uthsc.edu/pubmed/8010136
It is concluded that regular sauna bathing probably reduces the incidence of common colds, but further studies are needed to prove this. http://0-www.ncbi.nlm.nih.gov.opac.uthsc.edu/pubmed/2248758
Plasma noradrenaline increased about 100% at 80 D, 160% at 100 D and 310% at 80 DH. Adrenaline did not change. Plasma prolactin increased 2-fold at 80 D, 7-fold at 100 D and 10-fold at 80 DH. Blood concentrations of the beta-endorphin immunoreactivity at 100 D, adrenocorticotropic hormone (ACTH) at 100 D and 80 DH, growth hormone at 100 D and testosterone at 80 DH also increased, but cortisol at 80 D and 100 D decreased. http://0-www.ncbi.nlm.nih.gov.opac.uthsc.edu/pubmed/2759081
Sauna bathing facilitates the removal of hyperkeratotic scales in psoriasis, and the use of petrolatum, emollient creams or topical antipsoriatic regimens has been found to be beneficial for many patients. Dermatophytes and other infective microorganisms are easily killed by the heat of the sauna. http://0-www.ncbi.nlm.nih.gov.opac.uthsc.edu/pubmed/3218900 .
the data indicate that the maximum heat dose without obvious complications after localized hyperthermia in regions of the central nervous system (CNS) lies in the range of 40-60 min at 42-42.5°C or 10-30 min at 43°C. http://www.informaworld.com/smpp/content~db=all~content=a714030354?words=inflammation&hash=1434128621
Induction of heat shock proteins (Hsp72 and Hsp27) by hyperthermia and/or geranylgeranylacetone has demonstrated to protect the heart against such atrial remodelling http://www.informaworld.com/smpp/content~db=all~content=a913909528?words=inflammation&hash=1434128621
The results showed that local hyperthermia after second degree burn decreased the tissue injury and iNOS expression. It is also concluded that endogenous opioid response may have a key role in the above mentioned effects of post-burn local hyperthermia. http://www.informaworld.com/smpp/content~db=all~content=a755324288?words=inflammation&hash=1434128621
a heat shock pretreatment (WBH) can ameliorate the oxidative stress produced by a metabolic toxin (3-NP) capable of impairing energy supply and produce selective striatal degeneration. These data contribute to a better understanding of the potential for thermal stress to modulate the type of oxidative stress usually present in neurodegenerative disorders associated with metabolic defects. http://0-www.ncbi.nlm.nih.gov.opac.uthsc.edu/pubmed/19440936?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2
These results support the hypothesis that the hyperthermic response to opioids is mediated by the mu receptor and the hypothermic response is mediated by the kappa receptor in rats. http://0-www.ncbi.nlm.nih.gov.opac.uthsc.edu/pubmed/9103537?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=5
Control of hormonal stress reactivity by the endogenous opioid system http://0-www.sciencedirect.com.opac.uthsc.edu/science?_ob=ArticleURL&_udi=B6TBX-4RV7H0Y-1&_user=1202635&_coverDate=05%2F31%2F2008&_rdoc=1&_fmt=full&_orig=search&_cdi=5154&_sort=d&_docanchor=&view=c&_acct=C000051985&_version=1&_urlVersion=0&_userid=1202635&md5=6e12e9e0726928674b445e74ba1be1ef#secx8
The dynamic relationship between mu and kappa opioid receptors in body temperature regulation http://0-www.sciencedirect.com.opac.uthsc.edu/science?_ob=ArticleURL&_udi=B6T99-4HF5KTP-2&_user=1202635&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000051985&_version=1&_urlVersion=0&_userid=1202635&md5=4e09b96ef63efeab5df3d66c57a49065
Thermoregulatory defense mechanisms. http://0-www.mdconsult.com.opac.uthsc.edu/das/article/body/169729875-2/jorg=journal&source=&sp=22267221&sid=0/N/702993/1.html?issn=0090-3493
Heat shock proteins and neuromuscular disease. http://0-www.ncbi.nlm.nih.gov.opac.uthsc.edu/pubmed/15962334?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=33
The upregulation of PSA-NCAM by hyperthermia may have a significant impact on hippocampal plasticity, permitting induction of the complex molecular cascade responsible for neuroprotection. http://0-www.ncbi.nlm.nih.gov.opac.uthsc.edu/pubmed/17336079?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=20
the researchers used transgenic mice, which had high levels of HSP27 throughout the brain, spinal cord and other tissues. This was found to reduce mortality rate and neuronal cell death in the hippocampus, a part of the brain affected by neurological diseases. Similar results were also obtained when HSP27 was injected directly into the brain. http://www.eurekalert.org/pub_releases/2003-05/icos-rip053003.php
a brief genetic response to heat stress can increase a fruit fly's life span at normal temperatures. The finding uncovers a potential mechanism for aging because the capacity to moderate stress is a central function to regulating that aging mechanism. http://www.eurekalert.org/pub_releases/1997-11/BU-POPE-061197.php
Two small 'heat shock' proteins turn out to be crucial - faults in the coding genes lead to the CMT disease. Additional research has shown that these proteins play an important role in many other neurodegenerative disorders as well. This research moves us a step closer to the development of new therapies. http://www.eurekalert.org/pub_releases/2004-05/vfii-cio050704.php
The researchers discovered a new molecular relationship critical to keeping cells healthy across a long span of time: a protein called SIRT1, important for caloric restriction and lifespan and activated by resveratrol, regulates heat shock factor 1 (HSF1), keeping it active. HSF1 in turn senses the presence of damaged proteins in the cell and elevates the expression of molecular chaperones to keep a cell's proteins in a folded, functional state. Regulation of this pathway has a direct beneficial effect to cells, the research shows. http://www.eurekalert.org/pub_releases/2009-02/nu-ape021909.php
HSP72 is in a family of proteins that form in the cells and protect organs in the body, such as the heart, against the type of extreme stress that a heart attack can cause. During stress, scientists believe, HSP72 can stabilize and refold damaged proteins, which is vital to preserving the heart if blood circulation is cut off. http://www.eurekalert.org/pub_releases/1998-12/UoF-EJTD-111298.php
We have shown for the first time that HSP60 plays an active part in the control of the inflammatory process in JDM. Thus, therapy aimed at the expansion of T-cells with regulatory capacities reacting to HSP60 could contribute to disease remission in patients with JDM. This conclusion opens up new perspectives for the understanding and approach for antigens in immunotherapy." http://www.eurekalert.org/pub_releases/2006-06/cwl-ior062106.php
In studies of the powerfully informative roundworm, C. elegans, UCSF scientists have discovered that a class of molecules found in the worms and in people can both prolong life in the worm and prevent the harmful accumulation of abnormal proteins that cause a debilitating Huntington's-like disease. The finding appears to be the first evidence in an animal of a link between aging and age-related disease. http://www.eurekalert.org/pub_releases/2003-05/uoc--rdc051303.php
They discovered that polyglutamine aggregates (one type of protein aggregate) are indeed toxic and that these unhealthy proteins bring healthy and otherwise normal proteins to aggregate with them. The researchers also found that the growth of these aggregates can be suppressed by molecular chaperones called heat shock proteins. http://www.eurekalert.org/pub_releases/2000-05/NU-Nssn-2105100.php
- In summary, these data suggest that intermittent hyperthermia during reloading attenuates oxidative stress and improves the rate of skeletal muscle regrowth during reloading after immobilization.
- http://jap.physiology.org/cgi/content/abstract/102/4/1702
Heat stress attenuates skeletal muscle atrophy in hindlimb-unweighted rats. http://0-jap.physiology.org.opac.uthsc.edu/cgi/content/full/88/1/359
An international team has carried out the study and found that people who sweat less when exercising are actually more likely to develop breathing problems -- the reason could be there is too little fluid in their airways. http://www.ncbi.nlm.nih.gov/pubmed/18641089
Hyperthermia induced changes in REM sleep, and apnea in piglets. http://www.ncbi.nlm.nih.gov/pubmed/8255687?ordinalpos=24&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Caused 16 fold in growth hormone that slowly declined towards the end of the study. Caused a 2.3 fold increase in prolactin that stayed consistent. Sauna use caused amenorrhoea in the women. http://www.ncbi.nlm.nih.gov/pubmed/3788622?ordinalpos=17&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Sweat secretion is often disturbed in patients with GH secretory disorders. Hyperhidrosis is a classic feature of acromegaly, and it has recently been shown that GH-deficient patients exhibit decreased sweating capacity. http://www.ncbi.nlm.nih.gov/pubmed/7593447?ordinalpos=22&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
"Heat acclimation lowers the aerobic metabolic rate and muscle and blood lactate accumulation during exercise in a cool as well as a hot environment." http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=4077800&ordinalpos=25&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
"Heat acclimation provides protection against permanent noise-induced hearing loss." http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15475665&ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Study shows that chronic exercise induced increased storage of norepinephrin among other catecholamines in the median preoptic area (a part of the hypothalamus). http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=4008413&ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Rats given an opioid antagonist (naloxone) did not reap the same cardio-protecting benefits from heat shock as controls did. http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=12003805&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Increased expression of HSP from hyperthermia in rats caused renal grafts harvest to be far more viable in donated animals. http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=11793032&ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Increased expression of HSP from hyperthermia in rats caused renal grafts harvest to be far more viable in donated animals. http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=11793032&ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Study showed a 3.6 fold increase in the production of HSP70i in mouse livers when exposed to whole body hyperthermia. This correlated with thermal tolerance. http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=11821493&ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Temperatures > or = 42 degrees C, maintained for > or = 25 min, inactivate approximately 25% of human immunodeficiency virus (HIV). http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=7882096&ordinalpos=29&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
There was a statistically significant increase in fatigue which returned to baseline values by 72 h. In contrast, a significant improvement in depression was evident through 72 h following treatment. http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=1607735&ordinalpos=94&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Sauna use (WBH) was used in patients with advanced cancer during chemotherapy. 138-patient study showed highly effective compared with chemo-only group. http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16859121&ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Via changes in gene expression of p53, bax, and bcl-2. (human cancer cells implanted in mice) http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17708613&ordinalpos=116&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Hippocampus, caudate nucleus, thalamus, and hypothalamus exhibited profound increases in water content after 4 hours of heat stress. http://0-www.ncbi.nlm.nih.gov.opac.uthsc.edu/pubmed/16671499?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=42
Results of this study stress the efficacy of hyperthermia in the treatment of advanced Peyronie's disease. Hyperthermia significantly reduced plaque size and penile curvature and led to an increase in mean scores of erectile function (EF) domain, while verapamil had no such effects. http://www.informaworld.com/smpp/content~db=all~content=a714030352?words=inflammation&hash=1434128621
References
- ↑ Matsushita, Kakushi; Akinori Masuda, Chuwa Tei (2008). "Efficacy of Waon therapy for fibromyalgia". Internal Medicine (Tokyo, Japan) 47 (16): 1473-1476. ISSN 1349-7235. PMID 18703857.
- ↑ Kukkonen-Harjula, K; P Oja, K Laustiola, I Vuori, J Jolkkonen, S Siitonen, H Vapaatalo (1989). "Haemodynamic and hormonal responses to heat exposure in a Finnish sauna bath". European Journal of Applied Physiology and Occupational Physiology 58 (5): 543-550. ISSN 0301-5548. PMID 2759081.
- ↑ 3.0 3.1 Narita, Minoru; Junaidi Khotib, Masami Suzuki, Satoru Ozaki, Yoshinori Yajima, Tsutomu Suzuki (2003-06). "Heterologous mu-opioid receptor adaptation by repeated stimulation of kappa-opioid receptor: up-regulation of G-protein activation and antinociception". Journal of Neurochemistry 85 (5): 1171-1179. ISSN 0022-3042. PMID 12753076.
- ↑ Capitano, Maegan L; Bradley R Ertel, Elizabeth A Repasky, Julie R Ostberg (2008-03). "Winner of the 2007 Society for Thermal Medicine Young Investigator Award. Fever-range whole body hyperthermia prevents the onset of type 1 diabetes in non-obese diabetic mice". International Journal of Hyperthermia: The Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 24 (2): 141-149. doi:. ISSN 0265-6736.
- ↑ Kokura, Satoshi; Satoko Adachi, Emiko Manabe, Katsura Mizushima, Takeshi Hattori, Toshimitsu Okuda, Nami Nakabe, Osamu Handa, Tomohisa Takagi, Yuji Naito, Norimasa Yoshida, Toshikazu Yoshikawa (2007-05). "Whole body hyperthermia improves obesity-induced insulin resistance in diabetic mice". International Journal of Hyperthermia: The Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 23 (3): 259-265. doi:. ISSN 0265-6736.
- ↑ Kokura, Satoshi; Satoko Adachi, Katsura Mizushima, Tetsuya Okayama, Takeshi Hattori, Toshimitsu Okuda, Nami Nakabe, Emiko Manabe, Takeshi Ishikawa, Osamu Handa, Tomohisa Takagi, Yuji Naito, Toshikazu Yoshikawa (2010). "Gene expression profiles of diabetic mice treated with whole body hyperthermia: A high-density DNA microarray analysis". International Journal of Hyperthermia: The Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 26 (2): 101-107. doi:. ISSN 1464-5157.
- ↑ Hotamisligil, G S; N S Shargill, B M Spiegelman (1993-01-01). "Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance". Science (New York, N.Y.) 259 (5091): 87-91. ISSN 0036-8075. PMID 7678183.
- ↑ 8.0 8.1 Kokura, S; N Yoshida, T Okuda, N Nakabe, N Sakamoto, Y Isozaki, T Hattori, O Handa, T Takagi, Y Naito, T Yoshikawa (2007-02). "Hyperthermia ameliorates 2,4,6-trinitrobenzene sulphonic acid-induced colitis in rats: the role of heat shock proteins". International Journal of Hyperthermia: The Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 23 (1): 17-28. ISSN 0265-6736.
- ↑ Sakamoto, N; S Kokura, T Okuda, T Hattori, K Katada, Y Isozaki, N Nakabe, O Handa, T Takagi, T Ishikawa, Y Naito, N Yoshida, T Yoshikawa (2005-11). "Heme oxygenase-1 (Hsp32) is involved in the protection of small intestine by whole body mild hyperthermia from ischemia/reperfusion injury in rat". International Journal of Hyperthermia: The Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 21 (7): 603-614. ISSN 0265-6736. PMID 16304713.
- ↑ Grogan, M; M M Redfield, K R Bailey, G S Reeder, B J Gersh, W D Edwards, R J Rodeheffer (1995-07). "Long-term outcome of patients with biopsy-proved myocarditis: comparison with idiopathic dilated cardiomyopathy". Journal of the American College of Cardiology 26 (1): 80-84. ISSN 0735-1097.
- ↑ Barsheshet, Alon; Iris Barshack, Pnina Keren, Gad Keren, Jacob George (2008-12). "Whole-body hyperthermia attenuates experimental autoimmune myocarditis in the rat". Cardiovascular Pathology: The Official Journal of the Society for Cardiovascular Pathology 17 (6): 375-381. doi:. ISSN 1879-1336.
- ↑ Tarner, Ingo H; Ulf Müller-Ladner, Christine Uhlemann, Uwe Lange (2009-04). "The effect of mild whole-body hyperthermia on systemic levels of TNF-alpha, IL-1beta, and IL-6 in patients with ankylosing spondylitis". Clinical Rheumatology 28 (4): 397-402. doi:. ISSN 1434-9949.
- ↑ Wagner, A C; H Weber, L Jonas, H Nizze, M Strowski, F Fiedler, H Printz, H Steffen, B Göke (1996-11). "Hyperthermia induces heat shock protein expression and protection against cerulein-induced pancreatitis in rats". Gastroenterology 111 (5): 1333-1342. ISSN 0016-5085.
- ↑ 14.0 14.1 Bhagat, Lakshmi; Vijay P Singh, Albert M Song, Gijs J D van Acker, Sudhir Agrawal, Michael L Steer, Ashok K Saluja (2002-01). "Thermal stress-induced HSP70 mediates protection against intrapancreatic trypsinogen activation and acute pancreatitis in rats". Gastroenterology 122 (1): 156-165. ISSN 0016-5085.
- ↑ Paz, Ziv; Sharon Freeman, Michal Horowitz, Haim Sohmer (2004-12). "Prior heat acclimation confers protection against noise-induced hearing loss". Audiology & Neuro-Otology 9 (6): 363-369. doi:. ISSN 1420-3030.
- ↑ Kihara, Takashi; Sadatoshi Biro, Yoshiyuki Ikeda, Tsuyoshi Fukudome, Takuro Shinsato, Akinori Masuda, Masaaki Miyata, Shuichi Hamasaki, Yutaka Otsuji, Shinichi Minagoe, Suminori Akiba, Chuwa Tei (2004-12). "Effects of repeated sauna treatment on ventricular arrhythmias in patients with chronic heart failure". Circulation Journal: Official Journal of the Japanese Circulation Society 68 (12): 1146-1151. ISSN 1346-9843. PMID 15564698.
- ↑ Sorensen, K E; D S Celermajer, D Georgakopoulos, G Hatcher, D J Betteridge, J E Deanfield (1994-01). "Impairment of endothelium-dependent dilation is an early event in children with familial hypercholesterolemia and is related to the lipoprotein(a) level". The Journal of Clinical Investigation 93 (1): 50-55. doi:. ISSN 0021-9738.
- ↑ Drexler, H; D Hayoz, T Münzel, B Hornig, H Just, H R Brunner, R Zelis (1992-06-15). "Endothelial function in chronic congestive heart failure". The American Journal of Cardiology 69 (19): 1596-1601. ISSN 0002-9149. PMID 1598876.